Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Members of the metzincin family of metalloproteinases have long been considered merely
degradative enzymes for extracellular matrix molecules. Recently, however, there has been …

Matrix metalloproteinases (MMPs) have been shown to be key players in both extracellular
matrix remodeling and cell migration during cancer metastasis. MMP-14, a membrane …

Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were
originally identified as endogenous inhibitors of matrixin and adamalysin endopeptidase …

The zinc‐dependent matrix metalloproteinases (MMP s) are key enzymes associated with
extracellular matrix (ECM) remodeling; they play critical roles under both physiological and …

Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly
influenced by the surrounding microenvironment of the tumor. Therefore, the ability to …

The members of the tissue inhibitor of metalloproteinase (TIMP) family (TIMP-1, 2, 3, 4) are
prominently appreciated as natural inhibitors of cancer-promoting metalloproteinases …

The mechanisms of tumor cell dissemination and the contribution of membrane trafficking in
this process are poorly understood. Through a functional siRNA screening of human RAB …

Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous
proteins that primarily function to inhibit the activities of proteases such as the matrix …

Lymphatic dysfunctions are associated with several human diseases, including
lymphedema and metastatic spread of cancer. Although it is well recognized that lymphatic …