Centromeres are the chromosomal domains required to ensure faithful transmission of the
genome during cell division. They have a central role in preventing aneuploidy, by …

Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …

Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …

Execution of the DNA damage response (DDR) relies upon a dynamic array of protein
modifications. Using quantitative proteomics, we have globally profiled ubiquitination …

To maintain genome function and stability, DNA sequence and its organization into
chromatin must be duplicated during cell division. Understanding how entire chromosomes …

Carriers of BRCA1 germline mutations are predisposed to breast and ovarian cancers.
Accumulated evidence shows that BRCA1 is quickly recruited to DNA lesions and plays an …

The view of DNA packaging into chromatin as a mere obstacle to DNA repair is evolving. In
this review, we focus on histone variants and heterochromatin proteins as chromatin …

Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …

Centromeres direct chromosome inheritance, but in multicellular organisms their positions
on chromosomes are primarily specified epigenetically rather than by a DNA sequence. The …

Phosphorylation of histone variant H2AX at serine 139, named γH2AX, has been widely
used as a sensitive marker for DNA double-strand breaks (DSBs). γH2AX is required for the …