Mitochondria: a Promising Convergent Target for the treatment of amyotrophic lateral sclerosis

T Cunha-Oliveira, L Montezinho, RF Simões… - Cells, 2024 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …

Stem cells as new agents for the treatment of infertility: current and future perspectives and challenges

V Volarevic, S Bojic, J Nurkovic… - BioMed Research …, 2014 - Wiley Online Library
Stem cells are undifferentiated cells that are present in the embryonic, fetal, and adult stages
of life and give rise to differentiated cells that make up the building blocks of tissue and …

Human motor neurons with SOD1-G93A mutation generated from CRISPR/Cas9 gene-edited iPSCs develop pathological features of amyotrophic lateral sclerosis

BW Kim, J Ryu, YE Jeong, J Kim… - Frontiers in cellular …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
gradual degeneration and elimination of motor neurons (MNs) in the motor cortex …

Pathological roles of reactive oxygen species in male reproduction

S Chakraborty, S Roychoudhury - … Update on Male Infertility-Volume One, 2022 - Springer
Reactive oxygen species (ROS) are free radicals that have at least one unpaired electron
and play specific roles in the human body. An imbalance of ROS and antioxidant levels …

In vivo osteogenic differentiation of human turbinate mesenchymal stem cells in an injectable in situ-forming hydrogel

JS Kwon, SW Kim, DY Kwon, SH Park, AR Son, JH Kim… - Biomaterials, 2014 - Elsevier
Human turbinate mesenchymal stromal cells (hTMSCs) are an alternate source of adult stem
cells for regenerative medicine. In this work, we demonstrated that hTMSCs are easily …

Human induced pluripotent stem cell-derived vascular smooth muscle cells: differentiation and therapeutic potential

S Ayoubi, SP Sheikh, TV Eskildsen - Cardiovascular research, 2017 - academic.oup.com
Cardiovascular diseases remain the leading cause of death worldwide and current
treatment strategies have limited effect of disease progression. It would be desirable to have …

Current progress in stem cell therapy for male infertility

RF Adriansyah, R Margiana, S Supardi… - Stem Cell Reviews and …, 2023 - Springer
Infertility has become one of the most common issues worldwide, which has negatively
affected society and infertile couples. Meanwhile, male infertility is responsible for about …

In Situ-Forming Collagen/poly-γ-glutamic Acid Hydrogel System with Mesenchymal Stem Cells and Bone Morphogenetic Protein-2 for Bone Tissue Regeneration in a …

SH Cho, KK Shin, SY Kim, MY Cho, DB Oh… - Tissue Engineering and …, 2022 - Springer
Background: Bone marrow-derived mesenchymal stem cells (BMSCs) and bone
morphogenetic protein-2 (BMP-2) have been studied for bone repair because they have …

Development and dynamic regulation of mitochondrial network in human midbrain dopaminergic neurons differentiated from iPSCs

D Fang, Y Qing, S Yan, D Chen, SSD Yan - Stem cell reports, 2016 - cell.com
Mitochondria are critical to neurogenesis, but the mechanisms of mitochondria in
neurogenesis have not been well explored. We fully characterized mitochondrial alterations …

The next revolution in stroke care

R Teasell, D Rice, M Richardson… - Expert review of …, 2014 - Taylor & Francis
Stroke is the second leading cause of death and disability worldwide. Initiatives to decrease
the burden of stroke have largely focused on prevention and acute care strategies. Despite …