The polyphenolic profile and antioxidant activity of five vegetal extracts with hepatoprotective potential

L Costea, CL Chițescu, R Boscencu, M Ghica… - Plants, 2022 - mdpi.com
Oxidative stress is among the major triggers for many important human functional disorders,
which often lead to various metabolic or tissue diseases. The aim of the study is to obtain …

Ecotoxicological risk assessment of pesticides against different aquatic and terrestrial species: using mechanistic QSTR and iQSTTR modelling approaches to fill the …

Y Li, T Fan, T Ren, N Zhang, L Zhao, R Zhong… - Green Chemistry, 2024 - pubs.rsc.org
Owing to the continuous growth of farming activities, pesticides, a class of toxic and harmful
chemicals, are widely present in the environment and thus pose a potential risk to the …

Collagenases and their inhibitors: a review

S Wu, X Zhou, Z Jin, H Cheng - Collagen and Leather, 2023 - Springer
Hide and skin are complex tissue where the most abundant component is collagen. Matrix
metalloproteinases and bacterial collagenases are two kinds of collagenases that can …

The Influence of Phytosociological Cultivation and Fertilization on Polyphenolic Content of Menthae and Melissae folium and Evaluation of Antioxidant Properties …

EA Luță, A Biță, A Moroșan, DE Mihaiescu, M Ghica… - Plants, 2022 - mdpi.com
Since medicinal plants are widely used in treating various diseases, phytoconstituents
enrichment strategies are of high interest for plant growers. First of all, we investigated the …

Phytochemical Characterization and Antioxidant Activity Evaluation for Some Plant Extracts in Conjunction with Pharmacological Mechanism Prediction: Insights into …

EI Ilie, L Popescu, EA Luță, A Biță, AR Corbu… - Biomedicines, 2024 - mdpi.com
Lipid metabolism dysregulation can lead to dyslipidemia and obesity, which are major
causes of cardiovascular disease and associated mortality worldwide. The purpose of the …

Interaction of Some Asymmetrical Porphyrins with U937 Cell Membranes–In Vitro and In Silico Studies

DP Mihai, R Boscencu, G Manda, AM Burloiu, G Vasiliu… - Molecules, 2023 - mdpi.com
The aim of the present study was to assess the effects exerted in vitro by three asymmetrical
porphyrins (5-(2-hydroxyphenyl)-10, 15, 20-tris-(4-acetoxy-3-methoxyphenyl) porphyrin, 5-(2 …

In silico drug repurposing framework predicts repaglinide, agomelatine and protokylol as TRPV1 modulators with analgesic activity

C Andrei, DP Mihai, A Zanfirescu, GM Nitulescu… - Pharmaceutics, 2022 - mdpi.com
Pain is one of the most common symptoms experienced by patients. The use of current
analgesics is limited by low efficacy and important side effects. Transient receptor potential …

Development of Activity Rules and Chemical Fragment Design for In Silico Discovery of AChE and BACE1 Dual Inhibitors against Alzheimer's Disease

LQ Bao, D Baecker, DT Mai Dung, N Phuong Nhung… - Molecules, 2023 - mdpi.com
Multi-target drug development has become an attractive strategy in the discovery of drugs to
treat of Alzheimer's disease (AzD). In this study, for the first time, a rule-based machine …

Phytochemical Screening and Antioxidant Potential of Selected Extracts from Betula alba var. pendula Roth., Glycyrrhiza glabra L., and Avena sativa L.

A Ghica, V Drumea, A Moroșan, DE Mihaiescu… - Plants, 2023 - mdpi.com
The aim of the present study was to obtain, characterize, and evaluate the antioxidant
potential of some extracts obtained from the bark of Betula alba var. pendula Roth., the root …

Discovery of new microbial collagenase inhibitors

G Nitulescu, DP Mihai, A Zanfirescu, MS Stan… - Life, 2022 - mdpi.com
Simple Summary Antimicrobial resistance is spreading globally, making healthcare
specialists fear “a return to the dark age of medicine”. Great efforts are being made to …