Current advance of nanotechnology in diagnosis and treatment for malignant tumors
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
Penetrative and sustained drug delivery using injectable hydrogel nanocomposites for postsurgical brain tumor treatment
Postsurgical treatment of glioblastoma multiforme (GBM) by systemic chemotherapy and
radiotherapy is often inefficient. Tumor cells infiltrating deeply into the brain parenchyma are …
radiotherapy is often inefficient. Tumor cells infiltrating deeply into the brain parenchyma are …
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions
Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …
Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects
X Wang, H Ding, Z Li, Y Peng, H Tan, C Wang… - … and Targeted Therapy, 2022 - nature.com
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with an extremely low
survival rate. New and effective approaches for treatment are therefore urgently needed …
survival rate. New and effective approaches for treatment are therefore urgently needed …
Biomaterials and 3D bioprinting strategies to model glioblastoma and the blood–brain barrier
Glioblastoma (GBM) is the most prevalent and lethal adult primary central nervous system
cancer. An immunosuppresive and highly heterogeneous tumor microenvironment …
cancer. An immunosuppresive and highly heterogeneous tumor microenvironment …
Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy
Immunotherapy based on immune checkpoint inhibitors has evolved into a new pillar of
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …
Rationally designed drug delivery systems for the local treatment of resected glioblastoma
Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …
recurrence and poor prognosis. The standard of care, surgical resection followed by …
Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration
We are accumulating evidence that intestinal microflora, collectively named gut microbiota,
can alter brain pathophysiology, but researchers have just begun to discover the …
can alter brain pathophysiology, but researchers have just begun to discover the …
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
The blood–brain barrier (BBB) represents a key challenge in developing brain-penetrating
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …