Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …

Postmitotic neurons require persistently active controls to maintain terminal differentiation.
Unlike dividing cells, aberrant cell cycle activation in mature neurons causes apoptosis …

Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory
diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly …

Alzheimer's disease is the most prevalent neurodegenerative disease affecting older adults.
Primary features of Alzheimer's disease include extracellular aggregation of amyloid-β …

Transposable elements (TEs) are ubiquitous among eukaryotic species. Their evolutionary
persistence is likely due to a combination of tolerogenic, evasive/antagonistic, and …

The ability to mount an interferon-mediated innate immune response is essential in
protection against neurotropic viruses, but antiviral type I interferons also have neurotoxic …

Over 40% of the human genome is composed of retrotransposons, DNA species that hold
the potential to replicate via an RNA intermediate and are evolutionarily related to …

Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of
Alzheimer's disease (AD). Mobilization of transposable elements (TEs) in heterochromatic …

Misfolding protein aggregation inside or outside cells is the major pathological hallmark of
several neurodegenerative diseases. Among proteinopathies are neurodegenerative …

Cytosolic DNA sensors are a group of pattern recognition receptors (PRRs) that vary in
structures, molecular mechanisms, and origins but share a common function to detect …