Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review

G Yadav, S Ganguly - European journal of medicinal chemistry, 2015 - Elsevier
Benzimidazoles are the fused heterocyclic ring systems which form an integral part of
vitamin B 12 and have been luring many researchers all over the world to assess their …

Comprehensive review in current developments of benzimidazole‐based medicinal chemistry

RS Keri, A Hiremathad, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

Design, synthesis and ADMET prediction of bis-benzimidazole as anticancer agent

M Rashid - Bioorganic chemistry, 2020 - Elsevier
A new series of bis-benzimidazole clubbed with primary amine (3i-iii) and aromatic
aldehydes (4i-ix) were design and synthesize with an intention to search an anticancer lead …

Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents

M Rashid, A Husain, R Mishra - European journal of medicinal chemistry, 2012 - Elsevier
Starting from 4-(1H-benzo [d] imidazol-2-yl)-4-oxobutanehydrazide (1), twenty new 1-(1H-
benzo [d] imidazol-2-yl)-3-(1, 3, 4-oxadiazol-5-substituted derivatives-2-yl) propan-1-ones …

Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents

A Husain, M Rashid, M Shaharyar, AA Siddiqui… - European journal of …, 2013 - Elsevier
Two series of Benzimidazole clubbed with triazolo-thiadiazoles (5a–q, 5r, 5s and 5x–a1)
and triazolo-thiadiazines (5t–w) were synthesized with an aim to produce promising …

Recent advances in antiviral benzimidazole derivatives: a mini review

A Kanwal, M Ahmad, S Aslam, SAR Naqvi… - Pharmaceutical …, 2019 - Springer
Benzimidazole ring system is well known for its potential for various biological activities.
Recent research works have indicated the excellent antiviral potential of various derivatives …

Synthesis, biological evaluation, and molecular docking of new benzimidazole-1, 2, 3-triazole hybrids as antibacterial and antitumor agents

S Ahmed Saleh Alzahrani, S Nazreen… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of benzimidazole-1, 2, 3-triazole hybrids have been successfully accomplished
by the Click chemistry of different aromatic azides and propargylated benzimidazole (4). The …

A comprehensive review of N-heterocycles as cytotoxic agents

D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

Benzimidazole and piperidine containing novel 1, 2, 3‐triazole hybrids as anti‐infective agents: Design, synthesis, in silico and in vitro antimicrobial efficacy

JV Mendapara, MD Vaghasiya… - … of Biochemical and …, 2024 - Wiley Online Library
Cu alkyne‐azide cycloaddition was used to easily synthesize a library of novel heterocycles
containing benzimidazole and piperidine based 1, 2, 3‐triazole (7a–7l) derivatives. The …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …