The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the
systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve …

The world is currently experiencing the worst health pandemic since the Spanish flu in 1918—
the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome …

Sphingolipids have emerged as bioactive lipids involved in the regulation of many
physiological and pathological processes. In the retina, they have been established to …

Diabetic retinopathy (DR) is a major cause of visual deficits and blindness in the working-
age population and inflammatory response is a key event during DR. In this study, we …

Rationale: Pancreatic cancer is associated with poor prognosis with a 5-year survival rate of
less than 6%. Approximately 90% of pancreatic cancer patients harbor somatic mutations in …

Uveitis is a heterogeneous collection of diseases with polygenic and environmental
influences. This heterogeneity presents challenges in trial design and selection of end …

Several drug delivery systems have been proposed to overcome physiological barriers,
improving ocular bioavailability. Systemic routes are seldom used due to the blood-ocular …

Uveitis is characterized as a common cause of blindness worldwide. Aryl hydrocarbon
receptor (AhR), a ligand-activated nuclear receptor, has been implicated to play a role in …

Sphingolipids are both structural molecules that are essential for cell architecture and
second messengers that are involved in numerous cell functions. Ceramide is the central …

This review offers a comprehensive examination of the role of microglia in the pathogenesis
of autoimmune uveitis, an inflammatory eye disease with significant potential for vision …