Background Childhood maltreatment is associated with depression and cardiometabolic
disease in adulthood. However, the relationships with these two diseases have so far only …

Preclinical and clinical studies have shown that stress is one of the main environmental
factor playing a significant role in the pathogeny and life-course of bowel diseases (Bonaz …

Transdiagnostic approaches challenge traditional psychiatric classification systems.
Adverse childhood experiences (ACE) represent a transdiagnostic risk factor for …

Importance Approximately 9% of US adults experience major depression each year, with a
lifetime prevalence of approximately 17% for men and 30% for women. Observations Major …

Background Childhood trauma, low social support, and alexithymia are recognized as risk
factors for major depressive disorder (MDD). However, the mechanisms of risk factors …

Background Childhood trauma (CT) is associated with severe sequelae, including stress‐
related mental health disorders that can perpetuate long into adulthood. A key mechanism in …

Introduction: Schema therapy (ST) reduces depressive symptoms, but clinical trials have not
investigated its effectiveness for patients suffering from severe forms of depression and high …

Background Child maltreatment is a broadly confirmed risk factor for mental and physical
illness. Some psychological treatments specifically target mental health conditions …

BackgroundProfiling patients on a proposed 'immunometabolic depression'(IMD) dimension,
described as a cluster of atypical depressive symptoms related to energy regulation and …

Introduction: In clinical trials, mostly group-level treatment effects of repeated cross-sectional
measures are analyzed. However, substantial heterogeneity regarding individual symptom …