Most secreted proteins are transported through the “conventional” endoplasmic reticulum–
Golgi apparatus exocytic route for their delivery to the cell surface and release into the …

In eukaryotes, there is now compelling evidence that in addition to the conventional
endoplasmic reticulum–Golgi secretory pathway, there are additional routes for the export of …

The sorting of secreted cargo proteins and their export from the trans-Golgi network (TGN)
remains an enigma in the field of membrane trafficking; although the sorting mechanisms of …

Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. Here we report
that, unlike previously characterized cell lineages, differentiation of syncytiotrophoblast …

Multiple myeloma is a plasma cell neoplasm characterized by the production of unfolded
immunoglobulins, which cause endoplasmic reticulum (ER) stress and sensitivity to …

The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated
endonuclease (Cas) system, referred to as CRISPR/Cas system, has attracted significant …

CRISPR genome editing approaches theoretically enable researchers to define the function
of each human gene in specific cell types, but challenges remain to efficiently perform …

Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and
many human disorders, including pathological tissue fibrosis in major organs. How …

Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell
signaling, attachment and endocytosis. These interactions depend on the arrangement of …

Oocytes spend the majority of their lifetime in a primordial state. The cellular and molecular
biology of primordial oocytes is largely unexplored; yet, it is necessary to study them to …