▪ Abstract Recent advances—both experimental and theoretical—provide a tentative image
of the structures in Ca channels that make them exceptionally selective. The image is very …

Transmembrane ion channels play a crucial role in the existence of all living organisms.
They partition the exterior from the interior of the cell, maintain the proper ionic gradient …

A Poisson-Nernst-Planck-Fermi (PNPF) theory is developed for studying ionic transport
through biological ion channels. Our goal is to deal with the finite size of particle using a …

Numerical methods are proposed for an advanced Poisson-Nernst-Planck-Fermi (PNPF)
model for studying ion transport through biological ion channels. PNPF contains many more …

Calcium channels have highly charged selectivity filters (4 COO− groups) that attract cations
in to balance this charge and minimize free energy, forcing the cations (Na+ and Ca2+) to …

The anomalous mole fraction effect of L-type calcium channels is analyzed using a Fermi
like distribution with the experimental data of Almers and McCleskey [J. Physiol. 353, 585 …

Providing detailed methods for the study of transient receptor potential (TRP) channels and
their role in a wide variety of cellular functions, this book includes expression and functional …

Ion channels play an essential role in the communication between and within cells. Here
some of the different ion channel proteins and the roles they perform are introduced, before …

Cardiovascular function relies on complex servo-controlled regulation mechanisms that
involve both fast-acting feedback responses and long-lasting adaptations affecting the gene …

To establish a computer model for evaluating the binding affinity of phenylalkylamines
(PAAs) to T-type Ca2+ channels (TCCs), we created new homology models for both TCCs …