Advances in engineering human tissue models
CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …
the investigation and understanding of specific biological events and processes under …
Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications
Organs-on-a-chip, or OoCs, are microfluidic tissue culture devices with micro-scaled
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
J Dornhof, J Kieninger, H Muralidharan, J Maurer… - Lab on a Chip, 2022 - pubs.rsc.org
Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …
models for a more efficient and individualized cancer therapy. Currently, culture conditions …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
Artificial intelligence-powered microfluidics for nanomedicine and materials synthesis
Artificial intelligence (AI) is an emerging technology with great potential, and its robust
calculation and analysis capabilities are unmatched by traditional calculation tools. With the …
calculation and analysis capabilities are unmatched by traditional calculation tools. With the …
Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …
disease. To overcome the major challenges in cancer therapy, we need to have a better …
A three-dimensional (3D) organotypic microfluidic model for glioma stem cells–Vascular interactions
Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: from 3D modeling to clinical concepts
M Shahpouri, MA Adili-Aghdam, H Mahmudi… - Journal of Controlled …, 2023 - Elsevier
Hypoxia is a unique characteristic of the solid tumor microenvironment. Hypoxia contributes
to multi-drug resistance, metastasis and cancer relapse through numerous molecular …
to multi-drug resistance, metastasis and cancer relapse through numerous molecular …
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors
L Wan, CA Neumann, PR LeDuc - Lab on a Chip, 2020 - pubs.rsc.org
Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …