OBJECTIVE: Gross total resection (GTR) prolongs survival but is unfortunately not
achievable in the majority of patients with glioblastoma multiforme (GBM). Cytoreductive …

Object Currently, few medical options exist for refractory and atypical/anaplastic
meningiomas. New developments in chemotherapeutic options for meningiomas have been …

Leptomeningeal metastasis (LM) results from metastatic spread of cancer to the
leptomeninges, giving rise to central nervous system dysfunction. Breast cancer, lung …

While primary malignant brain tumors account for only two percent of all adult cancers, these
neoplasms cause a disproportionate amount of cancer-related disabilities and death. The …

BACKGROUND: A substantial body of evidence suggests that cytoreductive surgery is a
prerequisite to prolonging survival in patients with glioblastoma (GBM). OBJECTIVE: To …

The treatment of meningiomas is tailored to their histological grade. While World Health
Organization (WHO) grade I lesions can be treated with either surgery or external beam …

Hydroxyurea (HU), an orally administered chemotherapy, has become the de facto standard
chemotherapeutic agent in patients with surgically and radiation refractory meningiomas …

Glioblastoma multiforme (GBM) is a highly invasive brain tumor that develops florid
microvascular proliferation and hemorrhage. However, mechanisms that favor invasion …

Glioblastoma (GBM) is the most common primary adult intracranial malignancy and carries a
dismal prognosis despite an aggressive multimodal treatment regimen that consists of …

Characterization of healthy versus pathological tissue in the peritumoral area is confounded
by the presence of edema, making free water estimation the key concern in modeling tissue …