All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …

Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …

Cholesterol is an essential component of all cell membranes and particularly enriched in
myelin membranes. Myelin membranes are a major target of immune attacks in the chronic …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Astrocytes are important for maintaining cholesterol metabolism, glutamate uptake, and
neurotransmission. Indeed, inflammatory processes and neurodegeneration contribute to …

Differential microglial inflammatory responses play a role in regulation of differentiation and
maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is …

Background Multiple sclerosis (MS) therapeutic goals have traditionally been dichotomized
into two distinct avenues: immune-modulatory-centric interventions and pro-regenerative …

Macrophages play major roles in the pathophysiology of various neurological disorders,
being involved in seemingly opposing processes such as lesion progression and resolution …

Raman microspectroscopy is a vibrational spectroscopy technique used for investigating
molecular fingerprints of a wide range of liquid or solid samples. The technique can be …