Inside HDAC with HDAC inhibitors

P Bertrand - European journal of medicinal chemistry, 2010 - Elsevier
Histone deacetylase inhibitors are a large group of diverse molecules intrinsically able to
inhibit cell proliferation in various cancer cell lines. Their apoptotic effects have been linked …

From natural products to HDAC inhibitors: An overview of drug discovery and design strategy

X Qiu, L Zhu, H Wang, Y Tan, Z Yang, L Yang… - Bioorganic & Medicinal …, 2021 - Elsevier
Histone deacetylases (HDACs) play a key role in the homeostasis of protein acetylation in
histones and have recently emerged as a therapeutic target for numerous diseases. The …

Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis

H Hemmatazad, HM Rodrigues, B Maurer… - Arthritis & …, 2009 - Wiley Online Library
Objective We have recently shown a significant reduction in cytokine‐induced transcription
of type I collagen and fibronectin in systemic sclerosis (SSc) skin fibroblasts upon treatment …

Targeting histone deacetylases: opportunities for cancer treatment and chemoprevention

D Ruzic, N Djoković, T Srdić-Rajić, C Echeverria… - Pharmaceutics, 2022 - mdpi.com
The dysregulation of gene expression is a critical event involved in all steps of
tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene …

Histone deacetylase inhibitors (HDACIs). Structure—Activity relationships: History and new QSAR perspectives

E Pontiki, D Hadjipavlou‐Litina - Medicinal research reviews, 2012 - Wiley Online Library
Histone deacetylase (HDAC) inhibition is a recent, clinically validated therapeutic strategy
for cancer treatment. HDAC inhibitors (HDACIs) block angiogenesis, arrest cell growth, and …

Histone deacetylase inhibitors: design, structure-activity relationships and therapeutic implications for cancer

CM Marson - Anti-Cancer Agents in Medicinal Chemistry …, 2009 - ingentaconnect.com
Histone deacetylases (HDACs) remove acetyl groups from the tails of lysine residues of
histone protein in nuclear chromatin and also from acetylated sites in non-histone proteins …

Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression

C Charrier, J Clarhaut, JP Gesson, G Estiu… - Journal of medicinal …, 2009 - ACS Publications
New benzofuranones were synthesized and evaluated toward NCI-H661 non-small cell lung
cancer cells. Benzamide derivatives possessed micromolar antiproliferative and histone …

Domino Synthesis of Benzo-Fused β,γ-Unsaturated Ketones from Alkenylboronic Acids and N-Tosylhydrazone-Tethered Benzonitriles

M Plaza, M Paraja, L Florentino, C Valdés - Organic letters, 2019 - ACS Publications
The transition-metal-free domino reaction between alkenylboronic acids and N-
tosylhydrazones from o-(2-oxoalkyl)-and o-(3-oxoalkyl) benzonitriles leads to β, γ …

Preparation of trifluoromethylated dihydrocoumarins, indanones, and arylpropanoic acids by tandem superacidic activation of 2-(trifluoromethyl) acrylic acid with …

GKS Prakash, F Paknia, H Vaghoo… - The Journal of …, 2010 - ACS Publications
Indanones and coumarins are important intermediates for the convenient synthesis of many
pharmaceutical and biologically active compounds. Fluoroorganics play a vital role in the …

Synthesis of novel 6, 6a, 7, 8-tetrahydro-5H-naphtho [1, 2-e] pyrimido [4, 5-b][1, 4] diazepines under microwave irradiation as potential anti-tumor agents

B Insuasty, A García, J Quiroga, R Abonia… - European Journal of …, 2010 - Elsevier
A new series of 6, 6a, 7, 8-tetrahydro-5H-naphtho [1, 2-e] pyrimido [4, 5-b][1, 4] diazepines
4a-f and 5a-f were efficiently synthesized in good yields from the reaction of E-2-arylidene-1 …