Making choices: DNA replication fork recovery mechanisms
CM Kondratick, MT Washington, M Spies - Seminars in cell & …, 2021 - Elsevier
DNA replication is laden with obstacles that slow, stall, collapse, and break DNA replication
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …
forks. At each obstacle, there is a decision to be made whether to bypass the lesion, repair …
Fanconi anemia pathway as a prospective target for cancer intervention
Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least
one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and …
one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and …
FANCA promotes DNA double-strand break repair by catalyzing single-strand annealing and strand exchange
FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA
interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report that purified …
interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report that purified …
Holding all the cards—how fanconi anemia proteins deal with replication stress and preserve genomic stability
A Datta, RM Brosh Jr - Genes, 2019 - mdpi.com
Fanconi anemia (FA) is a hereditary chromosomal instability disorder often displaying
congenital abnormalities and characterized by a predisposition to progressive bone marrow …
congenital abnormalities and characterized by a predisposition to progressive bone marrow …
Stress and DNA repair biology of the Fanconi anemia pathway
Fanconi anemia (FA) represents a paradigm of rare genetic diseases, where the quest for
cause and cure has led to seminal discoveries in cancer biology. Although a total of 16 FA …
cause and cure has led to seminal discoveries in cancer biology. Although a total of 16 FA …
Maintenance of genome stability by Fanconi anemia proteins
Persistent dysregulation of the DNA damage response and repair in cells causes genomic
instability. The resulting genetic changes permit alterations in growth and proliferation …
instability. The resulting genetic changes permit alterations in growth and proliferation …
Human DNA exonuclease TREX1 is also an exoribonuclease that acts on single-stranded RNA
3′ repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune
disorders and the antiviral response. In this work, we show that TREX1 is also a RNA …
disorders and the antiviral response. In this work, we show that TREX1 is also a RNA …
Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25%
experience lowered glucose tolerance or frank diabetes. The underlying molecular …
experience lowered glucose tolerance or frank diabetes. The underlying molecular …
Human Fanconi anemia complementation group a protein stimulates the 5'flap endonuclease activity of FEN1
L Qian, F Yuan, P Rodriguez-Tello, S Padgaonkar… - PloS one, 2013 - journals.plos.org
In eukaryotic cells, Flap endonuclease 1 (FEN1) is a major structure-specific endonuclease
that processes 5'flapped structures during maturation of lagging strand DNA synthesis, long …
that processes 5'flapped structures during maturation of lagging strand DNA synthesis, long …
Head and neck cancer susceptibility and metabolism in Fanconi anemia
Simple Summary Germline loss-of-function mutations in any of over 20 known Fanconi
anemia (FA) genes cause the disorder FA. The FA pathway plays a key role in the repair of …
anemia (FA) genes cause the disorder FA. The FA pathway plays a key role in the repair of …