Drug-induced liver injury

RJ Andrade, N Chalasani, ES Björnsson… - Nature Reviews …, 2019 - nature.com
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

Drug induced liver injury: an update

M Garcia-Cortes, M Robles-Diaz, C Stephens… - Archives of …, 2020 - Springer
Drug induced liver injury (DILI) is a relatively rare hepatic condition in response to the use of
medications, illegal drugs, herbal products or dietary supplements. It occurs in susceptible …

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Drug-induced liver injury: cascade of events leading to cell death, apoptosis or necrosis

A Iorga, L Dara, N Kaplowitz - International journal of molecular sciences, 2017 - mdpi.com
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent
such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury …

Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice

M Villanueva-Paz, L Morán, N López-Alcántara… - Antioxidants, 2021 - mdpi.com
Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Novel 3D culture systems for studies of human liver function and assessments of the hepatotoxicity of drugs and drug candidates

VM Lauschke, DFG Hendriks, CC Bell… - Chemical research in …, 2016 - ACS Publications
The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives

RJ Fontana - Gastroenterology, 2014 - Elsevier
Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of
drug dose, route, or duration of administration. Furthermore, idiosyncratic DILI is not a single …

Drug-induced liver injury

MD Leise, JJ Poterucha, JA Talwalkar - Mayo clinic proceedings, 2014 - Elsevier
Drug hepatoxicity can be nonidiosyncratic (predictable), as in the case of acetaminophen, or
idiosyncratic (unpredictable). This review article focuses primarily on idiosyncratic drug …

Drug‐induced liver injury: advances in mechanistic understanding that will inform risk management

M Mosedale, PB Watkins - Clinical Pharmacology & …, 2017 - Wiley Online Library
Drug‐induced liver injury (DILI) is a major public health problem. Intrinsic (dose‐dependent)
DILI associated with acetaminophen overdose is the number one cause of acute liver failure …

An updated review of the molecular mechanisms in drug hypersensitivity

CB Chen, R Abe, RY Pan, CW Wang… - Journal of …, 2018 - Wiley Online Library
Drug hypersensitivity may manifest ranging from milder skin reactions (eg, maculopapular
exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions …