The RHO family GTPases: mechanisms of regulation and signaling
N Mosaddeghzadeh, MR Ahmadian - Cells, 2021 - mdpi.com
Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …
studies have convincingly demonstrated that altered signal transduction through RHO …
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
D Vigil, J Cherfils, KL Rossman, CJ Der - Nature Reviews Cancer, 2010 - nature.com
There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
DR Cook, KL Rossman, CJ Der - Oncogene, 2014 - nature.com
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …
has been implicated in cancer and other human diseases. However, in contrast to the direct …
Mechanical integration of actin and adhesion dynamics in cell migration
ML Gardel, IC Schneider… - Annual review of cell …, 2010 - annualreviews.org
Directed cell migration is a physical process that requires dramatic changes in cell shape
and adhesion to the extracellular matrix. For efficient movement, these processes must be …
and adhesion to the extracellular matrix. For efficient movement, these processes must be …
[HTML][HTML] Rho and Rac take center stage
K Burridge, K Wennerberg - Cell, 2004 - cell.com
Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …
effects of these proteins are on the actin cytoskeleton and it was these that first drew …
[HTML][HTML] Cell migration: Rho GTPases lead the way
M Raftopoulou, A Hall - Developmental biology, 2004 - Elsevier
Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …
variety of intracellular responses. They are best known as regulators of the actin …
[HTML][HTML] Rac activation and inactivation control plasticity of tumor cell movement
V Sanz-Moreno, G Gadea, J Ahn, H Paterson, P Marra… - Cell, 2008 - cell.com
Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type
movement is characterized by an elongated cellular morphology and requires extracellular …
movement is characterized by an elongated cellular morphology and requires extracellular …
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
KR Engelhardt, S McGhee, S Winkler, A Sassi… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: The genetic etiologies of the hyper-IgE syndromes are diverse.
Approximately 60% to 70% of patients with hyper-IgE syndrome have dominant mutations in …
Approximately 60% to 70% of patients with hyper-IgE syndrome have dominant mutations in …
Crystal structure of human cytochrome P450 2C9 with bound warfarin
PA Williams, J Cosme, A Ward, HC Angove… - Nature, 2003 - nature.com
Cytochrome P450 proteins (CYP450s) are membrane-associated haem proteins that
metabolize physiologically important compounds in many species of microorganisms, plants …
metabolize physiologically important compounds in many species of microorganisms, plants …