Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …

Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …

Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer's disease
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …

Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and
subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in …

Pyramidal neurons express rich repertoires of leucine-rich repeat (LRR)-containing
adhesion molecules with similar synaptogenic activity in culture. The in vivo relevance of this …

The role that astrocytes play in central nervous system (CNS) myelination is poorly
understood. We investigated the contribution of astrocyte‐derived factors to myelination and …

Abstract Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are
embedded in distinct information processing pathways. Their morphology, connectivity …

Maternal care acts as a strong environmental stimulus that can induce phenotypic plasticity
in animals and may also alter their microbial communities through development. Here, we …

The phenotype of an organism results from its genotype and the influence of the
environment throughout development. Even when using animals of the same genotype …

The immediate early gene Arc is a master regulator of synaptic function and a critical
determinant of memory consolidation. Here, we show that Arc interacts with dynamic …