In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one
of the prominent public health problems in tropical and subtropical regions with no effective …

Macrophages are key components of the innate immune system and exhibit extensive
plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus …

The nuclear receptor retinoic acid receptor-related orphan receptor gamma (RORγ or RORc)
is a key transcription factor for the production of pro-inflammatory cytokines implicated in the …

Impaired lung function is common in people with a history of tuberculosis. Host-directed
therapy added to tuberculosis treatment may reduce lung damage and result in improved …

Mycobacterium tuberculosis–specific (M. tuberculosis–specific) T cell responses associated
with immune control during asymptomatic latent tuberculosis infection (LTBI) remain poorly …

Background Tuberculosis has a major global impact. Immunocompetent hosts usually
control this disease, resulting in an asymptomatic latent tuberculosis infection (LTBI) …

Host immune responses at the site of Mycobacterium tuberculosis infection can mediate
pathogenesis of tuberculosis (TB) and onward transmission of infection. We hypothesized …

Mycobacterium tuberculosis (Mtb) leads to approximately 1.5 million human deaths every
year. In pulmonary tuberculosis (TB), Mtb must drive host tissue destruction to cause …