The intestinal immune defense system in insects

T Zeng, S Jaffar, Y Xu, Y Qi - International Journal of Molecular Sciences, 2022 - mdpi.com
Over a long period of evolution, insects have developed unique intestinal defenses against
invasion by foreign microorganisms, including physical defenses and immune responses …

Recent trends in insect gut immunity

SA Khan, MAM Kojour, YS Han - Frontiers in Immunology, 2023 - frontiersin.org
The gut is a crucial organ in insect defense against various pathogens and harmful
substances in their environment and diet. Distinct insect gut compartments possess unique …

[PDF][PDF] Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis

MA Hanson, B Lemaitre - Disease Models & Mechanisms, 2023 - journals.biologists.com
Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host
defence. Recent studies have implicated these peptides in the clearance of aberrant cells …

Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life

D Destoumieux-Garzón… - … of the Royal …, 2024 - royalsocietypublishing.org
The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected
to rapid environmental changes. It harbours a diversified and fluctuating microbiota that …

The conceptual foundations of innate immunity: Taking stock 30 years later

T Pradeu, BPHJ Thomma, SE Girardin, B Lemaitre - Immunity, 2024 - cell.com
While largely neglected over decades during which adaptive immunity captured most of the
attention, innate immune mechanisms have now become central to our understanding of …

Modulation of immunity by tryptophan microbial metabolites

S Li - Frontiers in Nutrition, 2023 - frontiersin.org
Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and
exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway …

Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth in Drosophila

H Nagai, LAE Nagai, S Tasaki, R Nakato, D Umetsu… - Developmental Cell, 2023 - cell.com
Post-developmental organ resizing improves organismal fitness under constantly changing
nutrient environments. Although stem cell abundance is a fundamental determinant of …

Steroid hormone regulation of innate immunity in Drosophila melanogaster

SA Keith - Plos Genetics, 2023 - journals.plos.org
Endocrine signaling networks control diverse biological processes and life history traits
across metazoans. In both invertebrate and vertebrate taxa, steroid hormones regulate …

[HTML][HTML] Vibrio cholerae arrests intestinal epithelial proliferation through T6SS-dependent activation of the bone morphogenetic protein pathway

X Xu, E Foley - Cell Reports, 2024 - cell.com
To maintain an effective barrier, intestinal progenitor cells must divide at a rate that matches
the loss of dead and dying cells. Otherwise, epithelial breaches expose the host to systemic …

In pursuit of understanding the rumen microbiome

RA Sanjorjo, T Tseten, MK Kang, M Kwon, SW Kim - Fermentation, 2023 - mdpi.com
The rumen plays an indispensable role in ruminants to utilize ligno-cellulosic material and
convert non-protein nitrogen into nutrients otherwise unavailable for human consumption …