The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …

Lympho–stromal interactions in multiple microenvironments within the thymus have a crucial
role in the regulation of T-cell development and selection. Recent studies have implicated …

The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V (D) J
recombination, a series of genomic rearrangements that occur specifically in developing …

Abstract Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that
TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8 …

Abstract Framework monoclonal antibodies have identified a population of human
lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) α-and β …

The search for the genes encoding the T-cell receptor α and β chains revealed a third gene,
T γ (ref. 1), which shares with the T α (refs 2–7) and T β (refs 8–15) genes a number of …

The T-cell repertoire is elaborated by a still poorly understood process during which
precursor cells arising in the bone marrow seed the thymus to provide a starting point for …

Before TCR rearrangements, T cell progenitors are committed not only to the ap and yJ T
cell lineage but also to various subsets of both lineages. In the mouse, distinct yJ T cell …

T cells bearing T cell receptor (TCR) y and 6 chain heterodimers are first generated early in
ontogeny. They form distinct subsets that differ in their TCR rep ettoires and tissue …

IN T-cell precursors, the T-cell-receptor β chain is expressed before the T-cell-receptor α
chain1, 2 and is sufficient to advance T-cell development in the absence of T-cell receptor α …