Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an intrinsically fluorescent
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …

The function of several G protein–coupled receptors (GPCRs) exhibits cholesterol sensitivity.
Cholesterol sensitivity of GPCRs could be attributed to specific sequence and structural …

Depression and anxiety are common, debilitating psychiatric conditions affecting millions of
people throughout the world. Current treatments revolve around selective serotonin …

Experimental evidence indicates that cannabidiol (CBD) induces anxiolytic and antiepileptic
effects through the activation of 5-HT1A receptors. These receptors are coupled to Gi/o …

Endocytosis is a key regulatory mechanism adopted by G protein-coupled receptors
(GPCRs) to modulate downstream signaling responses within a stringent spatiotemporal …

Endocytosis and intracellular trafficking constitute important regulatory features associated
with G protein-coupled receptor (GPCR) function. GPCR endocytosis involves several …

Serotonin1A receptors are important neurotransmitter receptors in the G protein-coupled
receptor (GPCR) family and modulate a variety of neurological, behavioral, and cognitive …

Purpose T-DM1 is an antibody–drug conjugate (ADC) consisting of trastuzumab and DM1
linked together. T-DM1 binds to human epidermal growth factor receptor-2 (HER2) in tumors …

Objective Rostral zona incerta (ZIR) evokes feeding by sending GABA transmission to
paraventricular thalamus (PVT). Although central serotonin (5-HT) signaling is known to play …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) is the most abundant
membrane phosphoinositide and cholesterol is an essential component of the plasma …