Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Preventing Gastrointestinal Bleeding in the Hospital Acid suppression is widely used to
lower the risk of gastrointestinal bleeding in critically ill patients, and the practice has spread …

Background Whether proton-pump inhibitors are beneficial or harmful for stress ulcer
prophylaxis in critically ill patients undergoing invasive ventilation is unclear. Methods In this …

Background The efficacy of prophylaxis against stress ulcers in preventing gastrointestinal
bleeding in critically ill patients has led to its widespread use. The side effects and cost of …

Purpose Stress ulcer prophylaxis (SUP) is commonly prescribed in the intensive care unit.
However, data from systematic reviews and conventional meta-analyses are limited by …

Purpose Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an
increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor …

Methods: In 10 ICUs, we randomized adult ICU patients anticipated to be mechanically
ventilated for greater than or equal to 48 hours to receive 40 mg of IV pantoprazole daily or …

Background Upper gastrointestinal (GI) bleeding due to stress ulcers contributes to
increased morbidity and mortality in people admitted to intensive care units (ICUs). Stress …

Background Pharmacologic stress ulcer prophylaxis (SUP) is recommended in critically ill
patients with high risk of stress-related gastrointestinal (GI) bleeding. However, as to patients …

Background The goal of this systematic review was to examine the efficacy and safety of
proton-pump inhibitors for stress ulcer prophylaxis in critically ill patients. Methods We …