Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

A Parthasarathy, EJ Borrego, MA Savka… - Journal of Biological …, 2021 - ASBMB
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …

Berberine in sepsis: effects, mechanisms, and therapeutic strategies

T Lv, C Zhang, L Hu, C Wang, S Li… - Journal of …, 2023 - Wiley Online Library
Sepsis is defined as a dysregulated immune response to infection that leads to multiple
organ dysfunction. To date, though a growing body of knowledge has gained insight into the …

[HTML][HTML] Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model

T Ouyang, H Yin, J Yang, Y Liu, S Ma - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Betulin is the primary anti-inflammatory component of Betula platyphylla suk. cortex (birch
bark), a time-honored Traditional Chinese Medicine (TCM) for healing trauma and tissue …

Combined use of bicyclol and berberine alleviates mouse nonalcoholic fatty liver disease

H Li, NN Liu, JR Li, B Dong, MX Wang… - Frontiers in …, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD), ranging from simple steatosis to nonalcoholic
steatohepatitis (NASH), is a liver disease worldwide without approved therapeutic drugs …

[HTML][HTML] Bicyclol ameliorates advanced liver diseases in murine models via inhibiting the IL-6/STAT3 signaling pathway

H Li, NN Liu, JR Li, MX Wang, JL Tan, B Dong… - Biomedicine & …, 2022 - Elsevier
Bicyclol, a synthetic hepatoprotective and anti-inflammatory agent approved in China, was
widely used to treat various hepatitis accompanied by elevated serum aminotransferases …

Bicyclol attenuates obesity-induced cardiomyopathy via inhibiting NF-κB and MAPK signaling pathways

Y Chen, W Lin, L Zhong, Z Fang, B Ye, Z Wang… - … Drugs and Therapy, 2023 - Springer
Purpose Schisandra is a well-known traditional Chinese medicine in East Asia. As a
traditional Chinese medicine derivative with Schisandra chinensis as raw material, bicyclol …

[HTML][HTML] Detecting free radicals post viral infections

VG Damle, K Wu, DJ Arouri, R Schirhagl - Free Radical Biology and …, 2022 - Elsevier
Free radical generation plays a key role in viral infections. While free radicals have an
antimicrobial effect on bacteria or fungi, their interplay with viruses is complicated and varies …

Bicyclol attenuates acute liver injury by activating autophagy, anti-oxidative and anti-inflammatory capabilities in mice

TM Zhao, Y Wang, Y Deng, XF Fan, XC Cao… - Frontiers in …, 2020 - frontiersin.org
Bicyclol, a novel synthetic antihepatitis drug, has been shown to protect against liver injury
via various pharmacological activities. The purpose of the current study was to further …

2-Amino-3-methylimidazo [4, 5-f] quinoline induced oxidative stress and inflammation via TLR4/MAPK and TLR4/NF-κB signaling pathway in zebrafish (Danio rerio) …

D Li, Z Li, C Qiu, B Peng, Y Zhang, H Sun… - Food and Chemical …, 2021 - Elsevier
Amino-3-methylimidazole [4, 5-f] quinoline (IQ) is a harmful substance, mainly existing in
protein-abundant thermally processed foods and polluted environments. This study …

Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis

J Luo, C Yang, X Luo, Y Yang, J Li, B Song, J Zhao… - Life sciences, 2020 - Elsevier
Aims This study aimed to investigate the therapeutic effect and molecular mechanism of
chlorogenic acid (CGA) on cyclophosphamide (CYP)-induced rat interstitial cystitis (IC) …