Advances in the development of personalized neoantigen-based therapeutic cancer vaccines
E Blass, PA Ott - Nature reviews Clinical oncology, 2021 - nature.com
Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …
cancers with the development and regulatory approval of various immune-checkpoint …
MHC-II neoantigens shape tumour immunity and response to immunotherapy
E Alspach, DM Lussier, AP Miceli, I Kizhvatov… - Nature, 2019 - nature.com
The ability of the immune system to eliminate and shape the immunogenicity of tumours
defines the process of cancer immunoediting. Immunotherapies such as those that target …
defines the process of cancer immunoediting. Immunotherapies such as those that target …
Memory T cell subsets, migration patterns, and tissue residence
SN Mueller, T Gebhardt, FR Carbone… - Annual review of …, 2013 - annualreviews.org
Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …
Infectious agents must be quickly and efficiently controlled by our immune system, but the …
TNF in the era of immune checkpoint inhibitors: friend or foe?
AY Chen, JD Wolchok, AR Bass - Nature Reviews Rheumatology, 2021 - nature.com
Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …
cancer and have emerged as a pillar of standard cancer care. However, their use is …
Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance …
ML Hwang, JR Lukens, TNJ Bullock - The Journal of Immunology, 2007 - journals.aai.org
CD4+ T cells are known to provide support for the activation and expansion of primary CD8+
T cells, their subsequent differentiation, and ultimately their survival as memory cells …
T cells, their subsequent differentiation, and ultimately their survival as memory cells …
CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes
R Bos, LA Sherman - Cancer research, 2010 - AACR
Abstract CD4 help for CD8+ T lymphocytes prevents tolerance and promotes the survival of
effector and memory CD8+ T cells. Here, we describe additional helper functions that …
effector and memory CD8+ T cells. Here, we describe additional helper functions that …
CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic …
A Fukunaga, M Miyamoto, Y Cho, S Murakami… - Pancreas, 2004 - journals.lww.com
Objective Recent studies have demonstrated the importance of tumor immunity for a cancer
patient's prognosis. In some types of cancer, it has been shown through …
patient's prognosis. In some types of cancer, it has been shown through …
Naive tumor-specific CD4+ T cells differentiated in vivo eradicate established melanoma
Y Xie, A Akpinarli, C Maris, EL Hipkiss… - Journal of Experimental …, 2010 - rupress.org
In vitro differentiated CD8+ T cells have been the primary focus of immunotherapy of cancer
with little focus on CD4+ T cells. Immunotherapy involving in vitro differentiated T cells given …
with little focus on CD4+ T cells. Immunotherapy involving in vitro differentiated T cells given …
Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester
BJC Quah, HS Warren, CR Parish - Nature protocols, 2007 - nature.com
This protocol outlines the carboxyfluorescein diacetate succinimidyl ester (CFSE) method for
following the proliferation of human lymphocytes in vitro and mouse lymphocytes both in …
following the proliferation of human lymphocytes in vitro and mouse lymphocytes both in …