The production of soluble amyloid-β oligomers (AβOs) and the activation of inflammation are
two important early steps in the pathogenesis of Alzheimer's disease (AD). The central role …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Accumulating studies suggest that overnutrition-associated obesity may lead to
development of type 2 diabetes mellitus and metabolic syndromes (MetS). MetS and its …

Whether cholesterol is implicated in the pathogenesis of Alzheimer's disease (AD) is still
controversial. Several studies that explored the association between lipids and/or lipid …

Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis
(NASH) are important causes of liver disease worldwide. Recently, a significant association …

Objective: We examined the incidence of mild cognitive impairment (MCI) and its potential
vascular risk factors in a prospective population-based study. Methods: An age-stratified …

People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical,
cellular, and biochemical manifestations that are currently not understood in combination …

Background: Metabolic syndrome (MetS) is associated with an increased risk of coronary
heart diseases and stroke. Results on the association of MetS with dementia and cognitive …

In this perspective we list the many clinical, histopathological, genetic and chemical
observations relating copper to Alzheimer's disease (AD). We summarize how the …