Traditionally, the development of a new solid dosage form is formulation-driven and less
focus is put on the design of a specific microstructure for the drug delivery system. However …

High shear wet granulation (HSWG) is considered a complicated and multivariate
pharmaceutical process that is influenced by a large number of variables derived from …

The use of X-ray microtomographic (XMT) methods in analysing particulate systems has
expanded rapidly in recent years with the availability of affordable desk-top apparatus. This …

Single drops impacting static powder beds were studied to explain the different resulting
granule structures. Three chemically similar powders with different physical properties …

The wet granulation process plays an important role in the pharmaceutical industry. With the
introduction of a Twin Screw Extruder (TSE), it allows the possibility of wet granulation to be …

The current study was to understand how process variables of high shear wet granulations
affect physical properties of granules and tablets. The knowledge gained was intended to be …

The mechanisms of the effect of process parameters on primary properties of granules
manufactured by wet granulation (size and density), bulk performance indicating properties …

Food powders such as maltodextrin are often produced in agglomerate form in spray
fluidized beds in order to enhance their user properties. These agglomerates mostly have …

The objective of the current work was to investigate the effect of liquid to solid ratio (L/S),
impeller speed and the wet massing time on the critical quality attributes of granules in a …

Results of a study on the influence of process parameters such as impeller speed,
granulation time and binder viscosity on granule strength and properties are reported. A …