Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

G-protein-coupled receptors (GPCRs), the largest family of signalling receptors, as well as
important drug targets, are known to activate extracellular-signal-regulated kinase (ERK)—a …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Activation of protein kinase Akt via its direct phosphorylation by mammalian target of
rapamycin (mTOR) complex 2 (mTORC2) couples extracellular growth and survival cues …

The mechanistic Target of Rapamycin (mTOR) is a growth-related kinase that, in the context
of the mTOR complex 1 (mTORC1), touches upon most fundamental cellular processes …

Amino acid (AA) availability is a robust determinant of cell growth through controlling
mechanistic/mammalian target of rapamycin complex 1 (mTORC1) activity. According to the …

Lysosomes have crucial roles in regulating eukaryotic metabolism and cell growth by acting
as signalling platforms to sense and respond to changes in nutrient and energy availability …

Molecular imaging is a non-invasive method to image and analyze the concentration and
activity of functional biomolecules in cells or in vivo at molecular level, and plays an …