Interactions between Borrelia burgdorferi and ticks

C Kurokawa, GE Lynn, JHF Pedra, U Pal… - Nature Reviews …, 2020 - nature.com
Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate
hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic …

Tick-pathogen interactions and vector competence: identification of molecular drivers for tick-borne diseases

J De la Fuente, S Antunes, S Bonnet… - Frontiers in cellular …, 2017 - frontiersin.org
Ticks and the pathogens they transmit constitute a growing burden for human and animal
health worldwide. Vector competence is a component of vectorial capacity and depends on …

Tick immune system: what is known, the interconnections, the gaps, and the challenges

AC Fogaça, G Sousa, DB Pavanelo, E Esteves… - Frontiers in …, 2021 - frontiersin.org
Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

Grappling with the tick microbiome

S Narasimhan, A Swei, S Abouneameh, U Pal… - Trends in …, 2021 - cell.com
Ixodes scapularis and Ixodes pacificus are the predominant vectors of multiple human
pathogens, including Borrelia burgdorferi, one of the causative agents of Lyme disease in …

[HTML][HTML] Current debates and advances in tick microbiome research

A Wu-Chuang, A Hodžić, L Mateos-Hernández… - Current research in …, 2021 - Elsevier
The main importance of ticks resides in their ability to harbor pathogens that can be
transmitted to terrestrial vertebrates including humans. Recently, studies have focused on …

Lipid hijacking: a unifying theme in vector-borne diseases

AJ O'Neal, LR Butler, A Rolandelli, SD Gilk, JHF Pedra - Elife, 2020 - elifesciences.org
Vector-borne illnesses comprise a significant portion of human maladies, representing 17%
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …

Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness

A Rolandelli, HJ Laukaitis-Yousey, HN Bogale… - Nature …, 2024 - nature.com
Uncovering the complexity of systems in non-model organisms is critical for understanding
arthropod immunology. Prior efforts have mostly focused on Dipteran insects, which only …

Vector specificity of arbovirus transmission

M Viglietta, R Bellone, AA Blisnick… - Frontiers in …, 2021 - frontiersin.org
More than 25% of human infectious diseases are vector-borne diseases (VBDs). These
diseases, caused by pathogens shared between animals and humans, are a growing threat …

Croquemort elicits activation of the immune deficiency pathway in ticks

AJ O'Neal, N Singh, A Rolandelli… - Proceedings of the …, 2023 - National Acad Sciences
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial
infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and …

Controlling ticks and tick-borne diseases… looking forward

J de la Fuente - Ticks and tick-borne diseases, 2018 - Elsevier
Tick-borne diseases (TBDs) represent a growing burden for human and animal health
worldwide. Several approaches including the use of chemicals with repellency and …