[HTML][HTML] Proactive and reactive roles of TGF-β in EMT-induced plasticity
Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …
Recent findings in the regulation of programmed death ligand 1 expression
X Shen, L Zhang, J Li, Y Li, Y Wang, ZX Xu - Frontiers in immunology, 2019 - frontiersin.org
With the recent approvals for the application of monoclonal antibodies that target the well-
characterized immune checkpoints, immune therapy shows great potential against both …
characterized immune checkpoints, immune therapy shows great potential against both …
Protein palmitoylation and its pathophysiological relevance
J Jin, X Zhi, X Wang, D Meng - Journal of cellular physiology, 2021 - Wiley Online Library
Protein palmitoylation, in which C16 fatty acid chains are attached to cysteine residues via a
reversible thioester linkage, is one of the most common lipid modifications and plays …
reversible thioester linkage, is one of the most common lipid modifications and plays …
The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics
ME Zaballa, FG van der Goot - Critical Reviews in Biochemistry …, 2018 - Taylor & Francis
S-Acylation (commonly referred to as S-palmitoylation) is a post-translational modification
consisting in the covalent attachment of an acyl chain to a cysteine residue of the target …
consisting in the covalent attachment of an acyl chain to a cysteine residue of the target …
Function of protein S-palmitoylation in immunity and immune-related diseases
Y Zhang, Z Qin, W Sun, F Chu, F Zhou - Frontiers in Immunology, 2021 - frontiersin.org
Protein S-palmitoylation is a covalent and reversible lipid modification that specifically
targets cysteine residues within many eukaryotic proteins. In mammalian cells, the …
targets cysteine residues within many eukaryotic proteins. In mammalian cells, the …
S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis
S-acylation is a reversible protein post-translational modification mediated by protein S-
acyltransferases (PATs). How S-acylation regulates plant innate immunity is our main …
acyltransferases (PATs). How S-acylation regulates plant innate immunity is our main …
The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML
X Shao, A Xu, W Du, T Xu, Y Huang… - Blood, The Journal …, 2023 - ashpublications.org
Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of
patients who receive the most intensive treatment inevitably experience disease relapse …
patients who receive the most intensive treatment inevitably experience disease relapse …
TSH combined with TSHR aggravates diabetic peripheral neuropathy by promoting oxidative stress and apoptosis in Schwann cells
J Fan, Q Pan, Q Gao, W Li, F Xiao… - Oxidative Medicine and …, 2021 - Wiley Online Library
Subclinical hypothyroidism (SCH) is associated with diabetic peripheral neuropathy (DPN);
however, the mechanism underlying this association remains unknown. This study is aimed …
however, the mechanism underlying this association remains unknown. This study is aimed …
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway
L Li, L Lu, Z Xiao, J Lv, H Huang, B Wu, T Zhao… - Science China Life …, 2024 - Springer
The BMP signaling pathway plays a crucial role in regulating early embryonic development
and tissue homeostasis. SMAD6 encodes a negative regulator of BMP, and rare variants of …
and tissue homeostasis. SMAD6 encodes a negative regulator of BMP, and rare variants of …