It is now clearly established that complex interactions between genes and environment are
involved in multiple aspects of neuropsychiatric disorders, from determining an individual's …

As NASA prepares for the first manned mission to Mars in the next 20 years, close attention
has been placed on the cognitive welfare of astronauts, who will likely endure extended …

Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of
caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and …

Neuroinflammation is believed to be one of the primary causes of cognitive impairment.
Previous studies showed that the antioxidant vitamin C (Vit C) performs many beneficial …

CNS inflammation is known to be an important pathogenetic mechanism of perioperative
neurocognitive disorder (PND), and iron overload was reported to participate in this process …

Sensorineural hearing loss (SNHL) has been demonstrated in many clinical reports as a risk
factor that promotes the development of cognitive impairment. However, the underlying …

Background Microglia, the mononuclear immune cells of the central nervous system (CNS),
are essential for the maintenance of CNS homeostasis. BAP31, a resident and ubiquitously …

A decline in estradiol (E2)-mediated cognitive benefits denotes a critical window for the
therapeutic effects of E2, but the mechanism for closing of the critical window is unknown …

Mild traumatic brain injury (mTBI) can lead to diffuse neurophysical damage as well as
cognitive and affective alterations. The nature and extent of behavioral changes after mTBI …

Learning and memory are known to depend on synaptic plasticity. Whereas the involvement
of plastic changes at excitatory synapses is well established, plasticity mechanisms at …