Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …

R-loops, three-strand nucleic acid structures, have emerged as crucial players in various
physiological processes, including the regulation of gene expression, DNA replication, and …

R-loops cause genome instability, disrupting normal cellular functions. Histone acetylation,
particularly by p300/CBP-associated factor (PCAF), is essential for maintaining genome …

RNA–DNA hybrids are epigenetic features of genomes that provide a diverse and growing
range of activities. Understanding of these functions has been informed by characterising …

Abstract Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons, which comprise
17% of the human genome, typically remain inactive in healthy somatic cells but are …

R‐loops are nucleic acid structures composed of a DNA: RNA hybrid with a displaced non‐
template single‐stranded DNA. Current approaches to identify and map R‐loop formation …

Exploring the intricate interplay within and between nucleic acids, as well as their
interactions with proteins, holds pivotal significance in unraveling the molecular complexities …

Abstract LINE1/L1 transposons, comprising around 20% of the human genome, typically
remain quiescent in healthy somatic cells but become activated in various cancer types. Our …

This thesis examines key factors activating the Alternative Lengthening of Telomeres (ALT)
Pathway and promoting cellular immortality in paediatric brain cancers. It also investigates …