Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …

Neural activity and behavior are both notoriously variable, with responses differing widely
between repeated presentation of identical stimuli or trials. Recent results in humans and …

The cholinergic system in the brain plays crucial roles in regulating sensory and motor
functions as well as cognitive behaviors by modulating neuronal activity. Understanding the …

γ-Aminobutyric acid (GABA) ergic inputs are strategically positioned to gate synaptic
integration along the dendritic arbor of pyramidal cells. However, their spatiotemporal …

Recent studies in mice reveal widespread cortical signals during task performance;
however, the various task-related and task-independent processes underlying this activity …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

During even the most quiescent behavioral periods, the cortex and thalamus express rich
spontaneous activity in the form of slow (< 1 Hz), synchronous network state transitions …

Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and
attention. They collectively innervate the entire cerebral cortex, differentially controlling …