SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

The post-translational modification of cysteine to diverse oxidative states is understood as a
critical cellular mechanism to combat oxidative stress. To study the role of cysteine oxidation …

Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …

Reversible protein S-nitrosylation regulates a wide range of biological functions and
physiological activities in plants. However, it is challenging to quantitively determine the S …

Connective tissue growth factor (CTGF; now often referred to as CCN2) is a secreted protein
predominantly expressed during development, in various pathological conditions that …

The three members of the endocrine-fibroblast growth factor (FGF) family, FGF19, 21, and 23
are circulating hormones that regulate critical metabolic processes. FGF23 stimulates the …

A contractile sheath and rigid tube assembly is a widespread apparatus used by
bacteriophages, tailocins, and the bacterial type VI secretion system to penetrate cell …

The acute phase reactant C-reactive protein (CRP) binds with high affinity to fibronectin
(FN), but this binding occurs only at pH 6.5 or lower, and the binding is inhibited by calcium …

In all eukaryotes, a functional mitotic spindle is essential for distributing duplicated
chromosomes into daughter cells. Mitotic spindle assembly involves highly ordered …