Dynamic alternative DNA structures in biology and disease
G Wang, KM Vasquez - Nature Reviews Genetics, 2023 - nature.com
Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
Origins of DNA replication in eukaryotes
Y Hu, B Stillman - Molecular cell, 2023 - cell.com
Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
G4access identifies G-quadruplexes and their associations with open chromatin and imprinting control regions
C Esnault, T Magat, A Zine El Aabidine… - Nature …, 2023 - nature.com
Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …
The structure and function of DNA G-quadruplexes
J Spiegel, S Adhikari, S Balasubramanian - Trends in Chemistry, 2020 - cell.com
Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …
G-quadruplexes: a promising target for cancer therapy
DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …
particular nucleic acid structure was discussed to play a role in malignant transformation and …
Non-B DNA: a major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome
Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
Guanine-rich DNA sequences occur throughout the human genome and can transiently form
G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic …
G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic …
G-quadruplex-binding proteins: promising targets for drug design
H Shu, R Zhang, K Xiao, J Yang, X Sun - Biomolecules, 2022 - mdpi.com
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …
the potential to form G4s are abundant in regulatory regions of the genome including …
G-quadruplex unwinding helicases and their function in vivo
M Sauer, K Paeschke - Biochemical Society Transactions, 2017 - portlandpress.com
The concept that G-quadruplex (G4) structures can form within DNA or RNA in vitro has
been long known and extensively discussed. In recent years, accumulating evidences imply …
been long known and extensively discussed. In recent years, accumulating evidences imply …
The diverse structural landscape of quadruplexes
G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …
Considerable research over the past three decades has led to in‐depth insight into these …