• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background—Infective endocarditis is a potentially lethal disease that has undergone major
changes in both host and pathogen. The epidemiology of infective endocarditis has become …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical
infections. It is a leading cause of bacteremia and infective endocarditis as well as …

Importance Infective endocarditis occurs in approximately 15 of 100 000 people in the
United States and has increased in incidence. Clinicians must make treatment decisions …

Infective endocarditis (IE), initially described more than 350 years ago, involves infection of
the endocardial surface of the heart. The clinical manifestations of IE can involve every …

Importance Several management strategies may improve outcomes in patients
withStaphylococcus aureusbacteremia. Objectives To review evidence of management …

Enterococci, one of the most common causes of hospital-associated infections, are
responsible for substantial morbidity and mortality. Enterococcus faecalis, the more common …

Infections related to implantable cardiac electronic devices (ICEDs), including pacemakers,
implantable cardiac defibrillators and cardiac resynchronization therapy devices, are …

Infections caused by Gram-positive pathogens remain a major public health burden and are
associated with high morbidity and mortality. Increasing rates of infection with Gram-positive …