Background Inflammation is thought to be an important mechanism for the development and
progression of obesity-related heart failure with preserved ejection fraction (HFpEF). In the …

Simple Summary Our growing aging population and increased prevalence of obesity have
become an emerging health problem as these conditions lead to the development of related …

Patients with heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF)
exhibit severe exercise intolerance that may be due, in part, to inappropriate cardiovascular …

BACKGROUND: We identified peripherally limited patients using cardiopulmonary exercise
testing and measured skeletal muscle oxygen transport and utilization during invasive single …

Background Obesity (OB) is highly prevalent in females after menopause, especially visceral
adipose tissue (VAT) accumulation which contributes to endothelial dysfunction. The …

Background The primary cause of dyspnea on exertion in heart failure with preserved
ejection fraction (HFpEF) is presumed to be the marked rise in pulmonary capillary wedge …

Heart failure with preserved ejection fraction (HFpEF) accounts for over 50% of all heart
failure cases nationwide and continues to rise in its prevalence. The complex, multi‐organ …

Heart failure with preserved ejection fraction (HFpEF) is increasing at an alarming rate
worldwide, with limited effective therapeutic interventions in patients. Sudden cardiac death …

Heart failure with preserved ejection fraction (HFpEF) is characterized by reduced ability to
sustain physical activity that may be due partly to disease-related changes in autonomic …

We investigated whether central or peripheral limitations to oxygen uptake elicit different
respiratory sensations and whether dyspnea on exertion (DOE) provokes unpleasantness …