The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

Myeloid-derived suppressor cells (MDSCs) are major negative regulators of immune
responses in cancer and chronic infections. It remains unclear if regulation of MDSC activity …

The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses
infection by Gram-negative bacteria, including Salmonella Typhimurium (S. Tm) and …

We investigated the role of the inflammasome effector caspases-1 and-11 during
Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells …

Abstract Background & Aims Advanced colorectal carcinoma (CRC) is characterized by a
high frequency of primary immune evasion and refractoriness to immunotherapy. Given the …

Intestinal homeostasis and the maintenance of the intestinal epithelial barrier are essential
components of host defense during gastrointestinal Salmonella Typhimurium infection. Both …

Implant associated infections represent a serious health burden in clinics since some
microorganisms are able to colonize biological surfaces or surfaces of indwelling medical …

Immunotherapy is becoming a popular treatment modality in combat against cancer, one of
the world's leading health problems. While tumor cells influence host immunity via …

Organelle remodeling is critical for cellular homeostasis, but host factors that control
organelle function during microbial infection remain largely uncharacterized. Here, a …