Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …

Anti-oestrogen-based therapies, often combined with a CDK4/6 inhibitor, are the current
standard-of-care first-line therapy for patients with advanced-stage hormone receptor …

Tamoxifen is commonly used for the treatment of patients with estrogen receptor‐positive
(ER+) breast cancer, but the acquired resistance to tamoxifen presents a critical challenge of …

Background although being central for the biology and druggability of hormone-receptor
positive, HER2 negative metastatic breast cancer (MBC), ESR1 and PIK3CA mutations are …

Background Decidual macrophages participate in immune regulation at the maternal–fetal
interface. Abnormal M1/M2 polarization of decidual macrophages might predispose immune …

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found
in solid tumors. 3D spheroid culture methods recreate more physiologically relevant …

Environmental hormones have attracted more attention because of their adverse impact on
the health and ecological security of human. Biodegradation is still an efficient tactics to …

Hormone supplementation is one of the common therapies for menopause-related
disorders. Among different tools, the ovariectomy (OVX) rodents are widely accepted as an …

Little is known of the brain mechanisms that mediate sex-specific autism symptoms. Here,
we demonstrate that deletion of the autism spectrum disorder (ASD)-risk gene, Pten, in …

Simple Summary Syndecans (SDCs; SDC1 to 4) are integral cell surface proteoglycans that
are expressed normally on various types of mammalian tissues. In cancer, SDCs' expression …