Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

[HTML][HTML] The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets are …

AC Van den Brink, EM Brouwer-Brolsma… - Advances in …, 2019 - Elsevier
As there is currently no cure for dementia, there is an urgent need for preventive strategies.
The current review provides an overview of the existing evidence examining the …

The relationship between obesity and cognitive health and decline

L Dye, NB Boyle, C Champ, C Lawton - Proceedings of the nutrition …, 2017 - cambridge.org
The relationship between obesity and cognitive impairment is important given the globally
ageing population in whom cognitive decline and neurodegenerative disorders will carry …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

[HTML][HTML] Mediterranean diet, cognitive function, and dementia: a systematic review of the evidence

SD Petersson, E Philippou - Advances in Nutrition, 2016 - Elsevier
A growing body of evidence suggests that adherence to the Mediterranean diet (MD) may
protect against cognitive decline and dementia. Many epidemiologic studies and several …

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

C Reitz, R Mayeux - Biochemical pharmacology, 2014 - Elsevier
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Mediterranean diet, stroke, cognitive impairment, and depression: a meta‐analysis

T Psaltopoulou, TN Sergentanis… - Annals of …, 2013 - Wiley Online Library
Objective This meta‐analysis aims to quantitatively synthesize all studies that examine the
association between adherence to a Mediterranean diet and risk of stroke, depression …

The projected effect of risk factor reduction on Alzheimer's disease prevalence

DE Barnes, K Yaffe - The Lancet Neurology, 2011 - thelancet.com
Summary At present, about 33· 9 million people worldwide have Alzheimer's disease (AD),
and prevalence is expected to triple over the next 40 years. The aim of this Review was to …

[HTML][HTML] Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study

L Clare, YT Wu, JC Teale, C MacLeod… - PLoS …, 2017 - journals.plos.org
Background Potentially modifiable lifestyle factors may influence cognitive health in later life
and offer potential to reduce the risk of cognitive decline and dementia. The concept of …

The benefits associated with volunteering among seniors: a critical review and recommendations for future research.

ND Anderson, T Damianakis, E Kröger… - Psychological …, 2014 - psycnet.apa.org
There is an urgent need to identify lifestyle activities that reduce functional decline and
dementia associated with population aging. The goals of this article are to review critically …