Lack of access to quality diagnostics remains a major contributor to health burden in
resource-limited settings. It has been more than 10 years since ASSURED (affordable …

With the advent of the antibiotic era, the overuse and inappropriate consumption and
application of antibiotics have driven the rapid emergence of multidrug-resistant pathogens …

Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …

In May 2014, the World Health Assembly officially approved the Draft Global Strategy and
Targets for Tuberculosis Prevention, Care and Control after 2015. 1 The target of the …

Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …

Tuberculosis is one of the oldest diseases known to humankind and it is currently a
worldwide threat with 8–9 million new active disease being reported every year. Among …

WHO estimates that 9 million people developed active tuberculosis in 2013 and 1· 5 million
people died from it. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) …

About 1· 3 million people died of tuberculosis in 2012, despite availability of effective drug
treatment. Barriers to improvements in outcomes include long treatment duration (resulting …

Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is the leading
cause of mortality worldwide due to a single infectious agent. The pathogen spreads …

Background The impact of human activities on the environmental resistome has been
documented in many studies, but there remains the controversial question of whether the …