Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is
associated with a decline in physiological function and adaptive capacity. Altered GI …

The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and
plays a key role in maintaining the host homeostasis. It encompasses several elements that …

Since the last century, advances in healthcare, housing, and education have led to an
increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related …

The vast mucosal surface of the intestine is patrolled by a large number of lymphocytes
forming the intestinal immune system. Like any other system in the body, this branch of the …

Diabetic foot ulcers (DFU) are one of the most common diabetes-related cause of
hospitalization and often lead to severe infections and poor healing. It has been recently …

Enteric defensins likely play a key role in the management of the human microbiome
throughout development. The functional and mechanistic diversity of defensins is much …

Pneumonia generates considerable negative impacts on the elderly. Despite the
widespread uses of vaccines and appropriate antibiotics, the morbidity and mortality of …

The oral innate immune response may diminish with aging. In the present study, the aim was
to examine human β-defensin (hBD) 1-3 and human neutrophil peptide (HNP)-1 levels in …

Lung diseases disproportionately affect elderly individuals. The lungs form a unique
environment: a highly elastic organ with gaseous exchange requiring the closest proximity of …

Male fetus and neonates show increased immune vulnerability compared to females, which
results in a higher risk of perinatal infections. These differences could partially be due to sex …