Heterocyclic compounds offer an enormous area for new lead molecules for drug discovery.
Till today, efforts are being continuously made to find appropriate treatment for the …

The furo-pyranone framework is widely present in the molecular structure of various
biologically potent natural products and un-natural small molecules, and it represents a …

The stereoselective synthesis of glycosyl chlorides using catalytic Appel conditions is
described. Good yields of α-glycosyl chlorides were obtained using a range of glycosyl …

Abstract The natural product (−)‐TAN‐2483B is a fungal secondary metabolite which
displays promising anti‐cancer and immunomodulatory activity. Our previous syntheses of …

The first total synthesis of (−)-TAN-2483B, a fungal metabolite possessing a densely
functionalized furo [3, 4-b] pyran-5-one framework, is achieved in 14 steps from d-mannose …

In the presence of a nucleophilic base, ring-fused gem-dibromocyclopropanes derived from
d-glycals undergo ring opening to give 2-deoxy-2-(E-bromomethylene) glycosides. Such …

The pyranopyran amide (2S, 4aR, 8aR)-6-oxo-2, 4a, 6, 8a-tetrahydropyrano [3, 2-b] pyran-2-
carboxamide, C9H9NO4, 3, was prepared by a chemoselective hydration of the …

Protein kinases act as key mediators of essential biochemical pathways through the
phosphorylation of protein substrates. Overactivation and abnormal functions of protein …

The natural product (-)-TAN-2483B (1) is a polyketide derived secondary metabolite isolated
from the fermentation broth of a filamentous fungus at Takeda Industries, Japan. This …

Risperidone is a second-generation antipsychotic used to treat psychiatric disorders such as
schizophrenia, bipolar disorder and autism. It targets dopamine D2 and serotonin 5-HT2A …