Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

Peripheral nerve injuries, particularly in the upper limb, may have devastating
consequences. The outcome of injury is determined by the amount of cellular damage, and …

We have used in vitro oligodendrocyte differentiation and the in vivo remyelination model,
the cuprizone model, to identify genes regulating oligodendrocyte function and …

Injuries and diseases of the peripheral nervous system (PNS) are common but frequently
irreversible. It is often but mistakenly assumed that peripheral neuron regeneration is robust …

Reliable and responsive tools for monitoring disease activity and treatment outcomes in
patients with neuropathies are lacking. With the emergence of ultrasensitive blood …

Previous studies demonstrated that Schwann cells (SCs) express distinct motor and sensory
phenotypes, which impact the ability of these pathways to selectively support regenerating …

Neurons of the peripheral nervous system are capable of extensive regeneration following
axonal injury. This regenerative response is accompanied by changes in gene expression in …

Protection of mucosal tissues of the oral cavity, intestines, respiratory tract, and urogenital
tract from the constant challenge of pathogens is achieved by the combined barrier function …

Abstract Background Schwann cells (SCs) play a crucial role in Wallerian degeneration after
peripheral nerve injury. The expression of genes in SCs undergo a series of changes, which …

Osteopontin (OPN) is a glycophosphoprotein expressed by several cell types and has pro-
adhesive, chemotactic, and cytokine-like properties. OPN is involved in a number of …