We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a
number of systemic hormones and transcription factors are known to regulate proliferation …

Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …

Two-dimensional (2D) cell cultures have been the standard for many different applications,
ranging from basic research to stem cell and cancer research to regenerative medicine, for …

Women show a lower incidence of cardiovascular diseases than age‐matched men, but this
benefit disappears after menopause. Oestrogen‐mediated vascular actions are mainly …

Background: Calciprotein particles (CPPs) are associated with the development of vascular
calcifications in chronic kidney disease. The role of endothelial cells (ECs) in this process is …

The purpose of this study was to evaluate in vivo endothelial function and nitric oxide (NO)-
dependent vasodilation between women in either menstrual or placebo pill phases of their …

Under specific conditions, such as catabolic stress or systemic inflammation, endogenous
nutrient production becomes insufficient and exogenous supplementation (eg., through …

The endothelium plays a fundamental role in the biological processes that ensure
physiological vessel integrity, synthesizing numerous substances that are capable of …