APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
Brain cell type-specific cholesterol metabolism and implications for learning and memory
Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
ABC transporters: human disease and pharmacotherapeutic potential
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are a 48-member
superfamily of membrane proteins that actively transport a variety of biological substrates …
superfamily of membrane proteins that actively transport a variety of biological substrates …
Emerging evidence of pathological roles of very-low-density lipoprotein (VLDL)
JK Huang, HC Lee - International journal of molecular sciences, 2022 - mdpi.com
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …
lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours …
Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration
RS Molday, FA Garces, JF Scortecci… - Progress in retinal and eye …, 2022 - Elsevier
ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …
preferentially localized along the rim region of rod and cone photoreceptor outer segment …
Role of ABCA7 in Human Health and in Alzheimer's Disease
S Dib, J Pahnke, F Gosselet - International Journal of Molecular Sciences, 2021 - mdpi.com
Several studies, including genome wide association studies (GWAS), have strongly
suggested a central role for the ATP-binding cassette transporter subfamily A member 7 …
suggested a central role for the ATP-binding cassette transporter subfamily A member 7 …
The shared role of cholesterol in neuronal and peripheral inflammation
Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
Role of ABCA1 in Cardiovascular Disease
J Wang, Q Xiao, L Wang, Y Wang, D Wang… - Journal of Personalized …, 2022 - mdpi.com
Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies
have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most …
have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most …
Therapeutic challenges in peripheral T-cell lymphoma
Y Luan, X Li, Y Luan, J Luo, Q Dong, S Ye, Y Li, Y Li… - Molecular Cancer, 2024 - Springer
Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of hematological
malignancies. Compared to our knowledge of B-cell tumors, our understanding of T-cell …
malignancies. Compared to our knowledge of B-cell tumors, our understanding of T-cell …
Blood-brain barrier transporters: An overview of function, dysfunction in Alzheimer's disease and strategies for treatment
The blood-brain-barrier (BBB) has a major function in maintaining brain homeostasis by
regulating the entry of molecules from the blood to the brain. Key players in BBB function are …
regulating the entry of molecules from the blood to the brain. Key players in BBB function are …