The development of precise and personalized medicine requires novel formulation
strategies to deliver the therapeutic payloads to the pathological tissues, producing …

The disulfide bond (− S− S−) is an extremely valuable functional group in a variety of
chemical and biological agents that display potent reactivity or biological activities (eg …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Conspectus Delivery remains a major obstacle restricting the potential action of small
molecular drugs as well as novel biologics which cannot readily enter cells without the help …

Nanotechnology has shown tremendous promise in target-specific delivery of drugs and
genes in the body. Although passive and active targeted-drug delivery has addressed a …

Dynamic combinatorial chemistry is defined as combinatorial chemistry under
thermodynamic control; that is, in a dynamic combinatorial library (DCL), all constituents are …

Liposomes, phospholipid vesicles with a bilayered membrane structure, have been widely
used as pharmaceutical carriers for drugs and genes, in particular for treatment of cancer. To …

Nanoscopic vehicles that stably encapsulate drug molecules and release them in response
to a specific trigger are of great interest due to implications in therapeutic applications …

Reversible covalent bond formation under thermodynamic control adds reactivity to self-
assembled supramolecular systems, and is therefore an ideal tool to assess complexity of …

The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to
the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be …