Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
[HTML][HTML] PET imaging of neuroinflammation in Alzheimer's disease
R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …
molecular imaging using positron emission tomography have provided insights into the time …
Neuroinflammation PET imaging: current opinion and future directions
P Jain, AM Chaney, ML Carlson… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however,
its exact role in vivo is yet to be fully understood. PET imaging enables investigation …
its exact role in vivo is yet to be fully understood. PET imaging enables investigation …
[HTML][HTML] Progress in PET imaging of neuroinflammation targeting COX-2 enzyme
Neuroinflammation and cyclooxygenase-2 (COX-2) upregulation are associated with the
pathogenesis of degenerative brain diseases such as Alzheimer's disease (AD), Parkinson's …
pathogenesis of degenerative brain diseases such as Alzheimer's disease (AD), Parkinson's …
Molecular docking studies and biological evaluation of isoxazole-carboxamide derivatives as COX inhibitors and antimicrobial agents
Non-steroidal anti-inflammatory drugs (NSAIDs) are considered one of the most commonly
used medications globally. Seventeen isoxazole-containing compounds with various …
used medications globally. Seventeen isoxazole-containing compounds with various …
The repertoire of small-molecule PET probes for neuroinflammation imaging: challenges and opportunities beyond TSPO
Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …
potentially injurious stimuli, which is closely associated with neurodegeneration and …
New thiazole carboxamide derivatives as COX inhibitors: design, synthesis, anticancer screening, in silico molecular docking, and ADME profile studies
The goal of this work was to create and test a new series of thiazole carboxamide derivatives
for their cyclooxygenase (COX) suppressor and anticancer effects. The compounds were …
for their cyclooxygenase (COX) suppressor and anticancer effects. The compounds were …
[HTML][HTML] Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly
used class of medications worldwide for the last three decades. Objectives This study aimed …
used class of medications worldwide for the last three decades. Objectives This study aimed …
Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome
A Bettiol, M Becatti, E Silvestri… - Clinical & …, 2021 - academic.oup.com
Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …
[HTML][HTML] The Brain–Gut Axis, an Important Player in Alzheimer and Parkinson Disease: A Narrative Review
Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease
(PD), are severe age-related disorders with complex and multifactorial causes. Recent …
(PD), are severe age-related disorders with complex and multifactorial causes. Recent …