Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Cancer causes a considerable amount of mortality in the world, while arthritis is an
immunological dysregulation with multifactorial pathogenesis including genetic and …

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid
leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to …

Viruses rely on host cells for energy and synthesis machinery required for genome
replication and particle assembly. Due to the dependence of viruses on host cells, viruses …

Silencing of tumor suppressor genes (TSGs) through epigenetic mechanisms, mainly via
abnormal promoter DNA methylation, is considered a main mechanism of tumorigenesis …

Breast cancer (BC) is one of the most common cancers in women and is a major cause of
female cancer-related deaths. BC is a multifactorial disease caused by the dysregulation of …

Background Most chemotherapeutics used in cancer therapies exhibit considerable side
effects to the patients. Thus, developing new chemo agents to treat cancer patients with …

Leukemia is a group of malignant diseases of clonal hematopoietic stem‑progenitor cells
and its pathological mechanisms remain to be elucidated. Genetic and epigenetic …

Acute lymphoblastic leukemia (ALL) is the most frequently diagnosed type of leukemia
among children. Although chemotherapy is a common treatment for cancer, it has a wide …

Abstract The NOTCH-Delta-HES signaling cascade is regarded as a double-edged sword
owing to its dual tumor-suppressor and oncogenic roles, in different cellular environments. In …